Mefenamic acid dosing, indications, interactions, adverse. Use lowest possible effective dosage and shortest duration of therapy consistent with patients treatment goals 15,2439. Mefenamic acid capsules usp, 250 mg par pharmaceutical. It works by stopping the bodys production of a substance that causes pain, fever, and inflammation. Thus a series of mefenamic acid based indole derivatives were designed via a rational approach. Available on line journal of chemical and pharmaceutical research. Synthesis and pharmacological evaluation of cyclodextrin. The target compounds were synthesized by acidcatalyzed condensation of 9 with the corresponding aromatic aldehydes scheme 1 4. A method of introducing different additives at different times during the process, i. The infrared absorption spectrum is concordant with the reference spectrum of mefenamic acid. The mixture was heated up to 60c and added to aqueous solution of metal chlorides 0,5 mol in 25 ml. May 25, 2016 mefenamic acid is a potent inhibitor of prostaglandin synthesis in vitro. Almasirad a1, tajik m, bakhtiari d, shafiee a, abdollahi m, zamani mj, khorasani r, esmaily h. Synthesis, spectroscopic, and thermal investigations of.
Extreme high moderate low section 1 chemical product and company identification product name mefenamic acid statement of hazardous nature considered a hazardous substance according to osha 29 cfr 1910. The chemical structure of paracetamol and mefenamic acid is shown in. Synthesis and preliminary pharmacological evaluation of. The purpose of the study was to synthesize prodrugs of mefenamic acid, to be used as anti inflammatory drug with fewer adverse effects. Consider potential benefits and risks of mefenamic acid therapy as well as alternative therapies before initiating therapy with the drug. The normal dose is 500mg three times a day, starting on the.
Preparation and evaluation of methyl salicylate counter. Mefenamic acid inhibits the activity of the enzymes cyclooxygenase i and ii, resulting in a decreased formation of precursors of prostaglandins and thromboxanes. Synthesis, biological evaluation and pharmacokinetic. Obat ini umumnya tersedia berupa mefenamic acid 500 mg atau 250 mg. Synthesis the synthesis of mefenamic acid ma and paracetamol p, mutual prodrug map is based on steglich esterification 18. Mefenamic acid digunakan secara jangka pendek 7 hari atau kurang. Therefore, the present study aims to develop a stability indicating method for mefenamic acid using rphplc technique. Available on line journal of chemical and pharmaceutical. Their design was prompted by the literature report on anticancer properties of mefenamic acid. This is not a list of all drugs or health problems that interact with mefenamic acid. Learn about side effects, warnings, dosage, and more.
Known hypersensitivity to mefenamic acid or any ingredient in the formulation. Different classes of solvents provide different polarity values, which influence the solubility of pharmaceutical solids. Talk with your doctor to see when you need to avoid taking mefenamic acid during pregnancy. A significant number of drugs that fail in clinical trials have been associated with safety issues, including unexpected drugdrug interactions ddi or lack of efficacy due to poor pharmacokinetics.
Check with your physician if you have any of the following. Mefenamic acid is well known antiinflammatory agent. Mefenamic acid is a nonsteroidal agent with antiinflammatory, analgesic and antipyretic action. It was anticipated that the wellknown acidaromatic nitrogen heterosynthon would provide a sufficient driving force for cocrystallization. The synthesis of mefenamic acid derivative is reacted between benzoyl derivatives and mefenamic acid via nucleophilic addition. Tyrosine and glycine derivatives as potential prodrugs.
Dissolution profile of mefenamic acid solid dosage forms. Pdf synthesis, characterization, theoretical studies and. Mefenamic acid counter irritant topical drug deliver nsaids abstract topical delivery of hydrophobic drug with good patient acceptance is a big challenge which is successfully handled by emulgels. They do not treat the disease that causes those symptoms. In the absence of additives, at optimized conditions, mef crystals were prepared in the size range of 0. Synthesis, biological evaluation and pharmacokinetic studies. Mefenamic acid ponstel is an oral drug used shortterm to treat pain, including menstrual cramps.
The synthesis method of mefenamic acid in the invention has the advantage that the production cost is low, the utilization of reaction raw materials is complete, the product purity is high, the environmental pollution is little, the operation safety is high, and the method is environmentally friendly and is applicable to industrial production. See what others have said about mefenamic acid, including the effectiveness, ease of use and side effects. Design and synthesis of new mefenamic acid derivatives as. Sigmaaldrich offers a number of mefenamic acid products. Cocrystal formation between nicotinamide and five fenamic acid derivative drugs flufenamic acid, niflumic acid, tolfenamic acid, mefenamic acid and meclofenamic acid was investigated using solutionbased and solidstate preparation methods. Synthesis of prodrugs mefenamic acid ma is 22,3dimethylphenylaminobenzoic acid, and synthesis of the prodrugs was carried out by the schottenbaumann method4,5. Synthesis, biological evaluation and pharmacokinetic studies of mefenamic acid nhydroxymethylsuccinimide ester prodrug as safer nsaid authors.
Synthesis, kinetics and pharmacological evaluation of mefenamic acid mutual prodrug. The temperature of reaction mixture was kept at 0oc, followed by the addition of n,nidimethyl. Mefloquine hydrochloride in which c is the concentration, in mg per ml, of usp mefenamic acid rs in the standard preparation. Mefenamic acid decreases inflammation and uterine contractions by a stillunknown mechanism. Mefenamic acid 10 mm, 50 ml of dichloromethane and paracetamol 10 mm were taken in 250 ml flat bottomed flask. Mefenamic acid concentrations reached during therapy have produced in vivo effects. The invention discloses a synthesis method of mefenamic acid. Drug development of mefenamic acid derivatives as analgesic. Each bluebanded, ivory capsule contains 250 mg of mefenamic acid for oral administration. The was to prepare emulgel of mefenamic acid, a nsaid, using gelling agent and methyl salicylates as counter irritant agent.
The was to prepare emulgel of mefenamic acid, a nsaid, using. In one small, randomized trial, the prevalence of preterm labor was significantly reduced by mefenamic acid compared with placebo. Mefenamic acid is used to relieve mild to moderate pain, including menstrual pain pain that happens before or during a menstrual period. Find patient medical information for mefenamic acid oral on webmd including its uses, side effects and safety, interactions, pictures, warnings and user ratings.
Aldulimia and rehab alhasani and emad yousif, year2015 adil ahmed a. Mefenamic acid is a potent inhibitor of prostaglandin synthesis in vitro. Mefenamic acid has analgesic, antiinflammatory, and antipyretic properties. Similar to other nsaids, mefenamic acid inhibits prostaglandin synthetase. In this video we are providing we are providing synthesis of mefenamic acid, which is very important for the gpat, niper, drug inspector, pharmacist as well as. Active ulceration or chronic inflammation of upper or lower gi tract. There are no adequate reports or wellcontrolled studies of mefenamic acid in pregnant women.
Solubility and dissolution thermodynamic data of mefenamic. Mefenamic acid is a white to greyishwhite, odorless, microcrystalline powder with a melting point of 230231c and water solubility of. The drug was covalently bonded to peg 1500 polyethylene glycol and peg 6000 as such and with a linker glycine. Stepwise use of additives for improved control over. Ponstel mefenamic acid is a member of the fenamate group of nonsteroidal antiinflammatory drugs nsaids. History of asthma, urticaria, or other sensitivity reaction precipitated by aspirin or other nsaias. According to the pharmacopoeia of the peoples republic of china 7, the method of identification testing of mefenamic acid in capsule and tablet preparations is based on light absorption spectrophotometry. Synthesis and analgesic activity of narylhydrazone derivatives of mefenamic acid. Mefenamic acid 22,3dimethylphenylaminobenzoic acid, an anthranilic acid derivative, is a nonsteroidal antiinflammatory drug nsaid which is widely used to relief mild to moderate pain. Mefenamic acid is an anthranilic acid and nonsteroidal antiinflammatory drug nsaid with antiinflammatory, antipyretic and analgesic activities. Synthesis of this class of compounds was carried out via a 3step method starting from the mefenamic acid.
Ahmed 3 and sama alahgbari 4 1,2 department of medicinal chemistry, faculty of pharmacy, university of science and technology, sanaa, yemen. Mefenamic acid, an anthranilic acid derivative, is a member of the fenamate group of nonsteroidal antiinflammatory drugs nsaids. Prostaglandins sensitize afferent nerves and potentiate the action of bradykinin in inducing pain in animal models. Synthesis and analgesic activity of narylhydrazone. Both mefenamic acid and darbepoetin alfa can increase the risk of hyperkalaemia hyperkalaemia is particularly notable when ace inhibitors or angiotensinii receptor antagonists are given with spironolactone or eplerenone. In patients with renal or hepatic impairment, clearance of metabolites may be decreased. Mefenamic acid is an nsaid, nsaids treat the symptoms of pain and inflammation. Mefenamic acid ingestion, usually in excess and over prolonged period is known to produce interstitial nephritis, or less commonly papillary necrosis, with acute renal failure 1. Synthesis, kinetics and pharmacological evaluation of. Mefenamic acid is a member of the anthranilic acid derivatives or fenamate class of nsaid drugs, and is used to treat mild to moderate pain, including menstrual pain, and is sometimes used to prevent migraines associated with menstruation. Aug 20, 2019 mefenamic acid oral capsule is a prescription drug used to treat mild to moderate pain and dysmenorrhea menstrual pain. Cocrystals of fenamic acids with nicotinamide crystal. Mefenamic acid cas 61687, synthesis, structure, density, melting point, boiling point.
It exhibits antiinflammatory, analgesic, and antipyretic activities. Mar 03, 2020 you may also need to avoid mefenamic acid at other times during pregnancy. Synthesis of narylhdyrazone derivatives of mefenamic acid 1122. Estimation and analysis of mefenamic acid suspension. Mefenamic acid inhibits the activity of the enzymes cyclooxygenase i and ii, resulting in a decreased formation of. Pdf synthesis of prodrugs of mefenamic acid and their in. The hydrazide derivative of mefenamic acid 9 scheme 1 was prepared according to the previously described methods 78. Mefenamic acid is classified as class ii on the basis of biopharmaceutical classification system bcs. In the present investigation mefenamic acid prodrug of. The first step of synthesis was preparation sodium salt of ligand by dissolution of mefenamic 1 mmol acid in 50 ml fresh precipitated aqueousethanol solution 1. Mefenamic acid is typically prescribed for oral administration.
Asif husain, department of pharmaceutical chemistry, faculty of pharmacy, hamdard university, new delhi110062, india. Pdf design and synthesis of new mefenamic acid derivatives. Synthesis and pharmacological evaluation of cyclodextrin conjugate prodrug of mefenamic acid s. The target compounds were synthesized by acid catalyzed condensation of 9 with the corresponding aromatic aldehydes scheme 1 4. If you have an allergy to mefenamic acid or any other part of mefenamic acid. Synthesis of prodrugs of mefenamic acid and their in vivo evaluation. Mefenamic acid 61687, c15h15no2, density, melting point. Mefenamic acid interactions bnfc content published by nice. Treatment of primary dysmenorrhoea inflammation and fever soft tissue and dental pain. Naveed s, qamar f, abbas ss, safdar s, ameer s, et al. Menorrhagia and its management the pharmaceutical journal. Synthesis and preliminary pharmacological evaluation of mefenamic acid and indomethacin derivatives as antiinflammatory agents with less git side effect mohammed ockba 1, sadik almekhlafi 2, abdulghany h. It has been found that mefenamic acid shows high solubility.
Mefenamic acid derivatives activity can be predicted before synthesized by molecular approach that. Stability indicating method for the determination of. Obat ini digunakan untuk mengobati nyeri ringan sampai sedang pada orang dewasa dan anakanak yang berusia setidaknya 14 tahun mefenamic acid juga digunakan untuk mengobati nyeri haid, sakit gigi, nyeri sendi, nyeri otot dll. Design and synthesis of new mefenamic acid derivatives as antiinflammatory agents article pdf available december 2011 with 219 reads how we measure reads. In this article, the solubility of mefenamic acid in different classes of organic solvents, including polar protic, dipolar aprotic, and apolar aprotics at a range of temperatures from 298 to 323 k are reported.
Dhaneshwar department of pharmaceutical chemistry, bharati vidyapeeth deemed university, poona college of pharmacy, erandwane, pune411 038, india. Halflife 5 times longer in preterm infants compared with adults. Synthesis of prodrugs of mefenamic acid and their in vivo evaluation article pdf available in international journal of pharmacy and pharmaceutical sciences 67 june 2014 with 3,789 reads. Synthesis, spectroscopic, and thermal investigations of metal. The mechanism of action of mefenamic acid, like that of other nsaids, is not completely understood but involves inhibition of cyclooxygenase cox1 and cox2. It is not widely used in the united states due to its side effects and high cost compared to other nsaid. The following conditions are contraindicated with this drug. Mefenamic acid is in a class of medications called nsaids.
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